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Syntara (SNT) investor relations material
Syntara Q1 2026 TU earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q1 2026 TU earnings summary27 Oct, 2025
Executive summary
Positive top-line Phase 2a data for amsulostat in myelofibrosis: 73% of patients achieved ≥50% symptom improvement and 44% achieved ≥25% spleen volume reduction at 6+ months, with durable benefits and no treatment-related serious adverse events up to 12 months.
FDA feedback provided a clear clinical development pathway for amsulostat in myelofibrosis.
Initiated AZALOX Phase 1b/2 trial in Germany for myelodysplastic neoplasms and two new Phase 1 studies for hypertrophic and keloid scars.
Appointed global myelofibrosis experts and industry leaders to support clinical development.
Financial highlights
Closing cash balance at 30 September 2025 was $14.4 million, down from $15.1 million at 30 June 2025.
Net cash outflow from operating activities was $0.6 million, significantly reduced from $3.74 million in the previous quarter.
Received $5.6 million R&D tax incentive during the quarter.
R&D and staff costs totaled $5.96 million, representing 92% of total net operating cash outflows.
Outlook and guidance
Five clinical studies are anticipated to deliver results in 2026, including ongoing and newly initiated trials in blood cancers and dermatology.
Finalizing the design of the next pivotal trial for amsulostat in myelofibrosis, informed by FDA feedback and advisory board input.
Amsulostat MF: Next trial design and patient focus?
MBU sale: What is the outlook for remaining payments?
What is the underlying operating cash burn rate?
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AGM 202519 Nov, 2025
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