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Rezolute
Rezolute (RZLT) investor relations material
Rezolute Q2 2026 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2026 earnings summary12 Feb, 2026
Executive summary
Focused on late-stage development of biologics for rare diseases, especially hyperinsulinism (HI).
Phase 3 sunRIZE trial for congenital HI did not meet primary or key secondary endpoints, though some efficacy signals were observed; all 59 participants entered the open-label extension, with many continuing on ersodetug monotherapy.
Phase 3 upLIFT trial for tumor HI is ongoing, with topline results expected in the second half of 2026.
Reduction in workforce by 29 employees in December 2025 to conserve cash after sunRIZE results.
Financial highlights
Net loss of $22.8 million for the quarter and $40.9 million for the six months ended December 31, 2025, compared to $15.7 million and $31.1 million in the prior year periods.
Operating expenses increased to $24.2 million for the quarter and $44.0 million for the six months, driven by higher R&D and G&A costs, including $1.5 million in one-time severance.
Cash, cash equivalents, and investments totaled $132.9 million as of December 31, 2025, down from $167.9 million as of June 30, 2025.
Working capital was $125.6 million as of December 31, 2025.
Outlook and guidance
Management believes current capital resources are sufficient to fund operations and planned activities for at least 12 months from the reporting date.
Additional equity or debt financing will be needed to meet long-term obligations and fund future development.
FDA meeting for congenital HI program expected by end of Q1 2026 under Breakthrough Therapy Designation; outcome may impact future plans and cash needs.
What caused the sunRIZE study effect?
EAP data: confidence for upLIFT primary endpoint?
Future OpEx impact of Dec 2025 reduction in force?
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Next Rezolute earnings date
Q3 202613 May, 2026
Rezolute
Next Rezolute earnings date
Q3 202613 May, 2026
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Frequently asked questions
Rezolute, Inc. is a clinical-stage biopharmaceutical company focused on developing therapies for metabolic diseases, particularly those related to chronic glucose imbalances. The company's lead product, RZ358, is a human monoclonal antibody currently in clinical trials aimed at treating congenital hyperinsulinism, a rare pediatric disorder. Additionally, Rezolute is working on RZ402, an oral plasma kallikrein inhibitor, intended for the treatment of diabetic macular edema. The company is headquartered in Redwood City, California, and its shares are listed on the NASDAQ.
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