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Oric Pharmaceuticals
Oric Pharmaceuticals (ORIC) investor relations material
Oric Pharmaceuticals Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary12 Feb, 2026
Development priorities and clinical programs
Focus on small molecule therapies targeting resistance in prostate, lung, and breast cancers.
Lead programs: rinzimetostat (PRC2 inhibitor) in prostate cancer and enozertinib (EGFR inhibitor) in lung cancer.
Phase III study for rinzimetostat to start in the first half of the year; dose optimization data expected in Q1.
Enozertinib phase III study may begin after additional data updates in the second half of the year.
Clinical data and differentiation
Rinzimetostat showed higher PSA response rates and a more favorable safety profile compared to Pfizer's mevrometostat in early data.
Differentiation is not required for commercial success in prostate cancer, but early signs suggest potential safety advantages.
Safety is a significant differentiator due to the community-based treatment setting and long therapy duration.
Dose optimization update in Q1 will focus on PSA responses and early durability, with 20-25 patients from one study arm.
Strategic and financial outlook
Decision on AR inhibitor partner for phase III will be based on data and strategic considerations; both apalutamide and darolutamide are viable.
Fully funded for the first phase III study, with cash runway into the second half of 2028.
No immediate need for a corporate partner; future partnerships may be considered for broader development.
What specific safety profile differentiates ORIC-944?
Quantify enozertinib's CNS benefit in lung cancer.
What drives choice between 2nd prostate or 1st-line EGFR?
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Next Oric Pharmaceuticals earnings date
Q4 202517 Feb, 2026
Oric Pharmaceuticals
Next Oric Pharmaceuticals earnings date
Q4 202517 Feb, 2026
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Frequently asked questions
Oric Pharmaceuticals Inc. is a clinical-stage biopharmaceutical company focused on discovering and developing innovative therapies aimed at overcoming resistance in cancer. The company is dedicated to addressing one of the most significant challenges in oncology by targeting resistance mechanisms to improve the efficacy and durability of cancer treatments. Oric's research is concentrated on three primary resistance pathways: innate resistance, acquired resistance, and bypass resistance. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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