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Herantis Pharma
Herantis Pharma (HRNTS) investor relations material
Herantis Pharma Company presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company presentation summary23 Jan, 2026
Clinical development highlights
Lead asset HER-096 is a synthetic peptide designed to mimic the active site of CDNF, targeting neurorestorative therapy for Parkinson's disease.
Phase 1 studies in healthy volunteers and Parkinson's patients showed strong safety, tolerability, and efficient brain penetration.
Biomarker data confirmed biological responses consistent with the drug's mechanism, supporting preclinical-to-clinical translatability.
No dose-limiting toxicities or unexpected adverse events were observed; all participants completed the studies.
Phase 2 proof-of-concept trial is planned, focusing on symptomatic improvement and disease modification in early-stage patients.
Mechanism of action and scientific rationale
HER-096 modulates the Unfolded Protein Response (UPR) pathway via interaction with GRP78, aiming to restore proteostasis and reduce neurodegeneration.
Demonstrates blood-brain barrier penetration and is administered subcutaneously 1–3 times per week.
Preclinical studies show HER-096 supports mitochondrial health and function, addressing key Parkinson's disease pathology.
Biomarker analyses reveal broad modulation of proteostasis, inflammation, and mitochondrial function, aligning with the proposed mechanism.
Sustained biological effects are observed despite short plasma half-life, supporting intermittent dosing.
Market opportunity and strategic positioning
Parkinson's disease affects 10 million people globally, with the pharmaceutical market projected to reach $11B by 2029 and $13B by 2034.
No disease-modifying therapies are currently available, positioning HER-096 as a potentially first-in-class treatment.
HER-096's differentiated mechanism and broad functionality offer potential in other CNS disorders.
The program is de-risked with human data, clear patient population, and defined dosing, making it attractive for partnering.
Intellectual property protection is established, with patents granted or pending in key markets.
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Next Herantis Pharma earnings date
H2 20255 Mar, 2026
Herantis Pharma
Next Herantis Pharma earnings date
H2 20255 Mar, 2026
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Frequently asked questions
Herantis Pharma Oyj is a Finnish biotechnology company focused on developing disease-modifying therapies for neurodegenerative diseases, particularly Parkinson's disease. The company's lead program centers around HER-096, a small synthetic chemical designed to mimic the activity of cerebral dopamine neurotrophic factor (CDNF). This treatment aims to address the progression of Parkinson's by protecting neurons and enhancing their function. The company is headquartered in Espoo, Finland, and its shares are listed on the Helsinki Stock Exchange.
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