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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Evommune (EVMN) investor relations material
Evommune Corporate Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate Presentation summary11 Dec, 2025
Addressing chronic inflammation and unmet medical needs
Chronic inflammation contributes to 3 out of 5 deaths globally and imposes an annual direct healthcare cost of at least $90B, with current therapies lacking efficacy and safety for many patients.
The mission is to address critical gaps in care for immune-mediated diseases by strategically selecting mechanisms with high probability of success and maintaining a steady cadence of new clinical programs.
Pipeline overview and clinical milestones
Two main programs in Phase 2: EVO756 (oral MRGPRX2 antagonist) for chronic spontaneous urticaria (CSU) and atopic dermatitis (AD), and EVO301 (IL-18BP fusion protein) for AD.
Three Phase 2 clinical data readouts are expected in 2026: EVO756 in CSU (H1), EVO756 in AD (H2), and EVO301 in AD (H1).
Additional preclinical programs are advancing toward clinical proof-of-concept in a broad range of inflammatory diseases.
EVO756 clinical data and development
EVO756 demonstrated robust clinical activity and safety in Phase 1 and 2 trials, with 30% complete response rate at 4 weeks in chronic inducible urticaria and well-tolerated dosing.
Pharmacokinetic modeling supports both QD and BID dosing regimens, with strong target engagement and dose-proportional pharmacokinetics.
Phase 2b trials in CSU and AD are dose-ranging, double-blind, and placebo-controlled, with topline data expected in 2026.
EVO756: How does safety impact dose selection?
Basis for EVO301 best-in-class EASI 90 claim?
How does Evommune prioritize pipeline development?
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Q4 202526 Mar, 2026
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