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Climb Bio
Climb Bio (CLYM) investor relations material
Climb Bio Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Guggenheim Securities Emerging Outlook: Biotech Summit 2026 summary12 Feb, 2026
Key milestones and clinical pipeline
Five clinical data readouts expected in 2024, including subcutaneous (subQ) and intravenous (IV) formulations for two antibodies targeting autoimmune diseases.
CD19 monoclonal antibody will have healthy volunteer subQ data in H1, and phase 1b/2 data in ITP, SLE, and PMN in H2.
APRIL-only sweeper antibody for IgA nephropathy will have mid-year data from a healthy volunteer study.
Parallel studies in China and Australia aim to accelerate pivotal trial readiness for IgAN.
Cash runway extends into 2028, covering all planned readouts.
CD19 antibody program and clinical strategy
CD19 antibody offers higher affinity and subQ formulation, aiming for differentiation from UPLIZNA.
Depleting mechanism seen as critical for efficacy in autoimmune diseases.
SubQ formulation may allow bridging from IV or serve as a standalone option, with dosing every six months.
PMN phase 2 study (45 patients, three doses) started in November, with dosing in 6-month cycles.
Regulatory path for PMN is a single phase 3 study with 150 patients, using complete renal remission as the primary endpoint.
Market opportunity and indication prioritization
PMN affects about 70,000 US patients, with two-thirds needing intervention.
ITP pursued for proof of mechanism and potential rapid pivotal advancement if durable response exceeds 20%.
SLE program is translational, with subtherapeutic dosing and parallel studies in China for lupus nephritis.
Indication expansion under consideration, leveraging subQ and IV options for broader autoimmune applications.
PMN: How does Phase 1b data differentiate budoprutug?
CLYM116: How does NHP data support differentiation?
How does Climb Bio manage diverse pipeline strategies?
Partial view of Summaries dataset, powered by Quartr API
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Next Climb Bio earnings date
Oppenheimer 36th Annual Healthcare Life Sciences Conference25 Feb, 2026
Climb Bio
Next Climb Bio earnings date
Oppenheimer 36th Annual Healthcare Life Sciences Conference25 Feb, 2026
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Eliem Therapeutics, Inc. is a biotechnology company focused on developing therapies for neuronal excitability disorders, which are associated with conditions like chronic pain, epilepsy, depression, and anxiety. The company’s approach involves advancing clinical-stage compounds that target neurological diseases, aiming to address significant unmet medical needs. Eliem Therapeutics is headquartered in Wilmington, Delaware, and its shares are listed on the NASDAQ.
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