Aktis Oncology
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Aktis Oncology (AKTS) investor relations material

Aktis Oncology Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary30 Mar, 2026

Executive summary

  • FDA cleared IND applications for AKY-2519, enabling a Phase 1b clinical trial in mid-2026 targeting B7-H3 in solid tumors.

  • Lead program AKY-1189, targeting Nectin-4, is enrolling in a Phase 1b trial and received FDA Fast Track designation in February 2026.

  • IPO in January 2026 raised $365.4M gross, supporting expansion and clinical development.

Financial highlights

  • Cash, cash equivalents, and marketable securities were $226.8M as of December 31, 2025; pro forma as adjusted cash post-IPO is $562.1M.

  • Collaboration revenue rose to $6.5M for 2025 from $1.5M in 2024, mainly from the Eli Lilly partnership.

  • R&D expenses increased to $67.5M in 2025 from $41.0M in 2024, driven by higher headcount and program advancement.

  • G&A expenses were $13.7M in 2025, up from $12.6M in 2024, reflecting business growth.

  • Net loss widened to $63.7M in 2025 from $44.0M in 2024, primarily due to increased R&D spending.

Outlook and guidance

  • Preliminary data from Part 1 of the AKY-1189 Phase 1b trial expected in Q1 2027.

  • Results from AKY-2519 imaging and dosimetry assessment expected mid-2026; Phase 1b trial to start mid-2026.

  • Early pipeline programs aim for development candidate nomination and IND-enabling activities in Q1 2027.

  • In-house GMP facility expected operational in H2 2026 to support clinical supply.

  • Pro forma cash position expected to fund operations into 2029.

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Q1 202615 May, 2026
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