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ZyVersa Therapeutics (ZVSA) investor relations material
ZyVersa Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Clinical-stage biopharma focused on renal and inflammatory diseases with two main drug platforms: VAR 200 (renal) and IC 100 (inflammatory).
No products approved or revenue generated; all resources devoted to R&D and organizational activities.
Lead renal candidate VAR 200 targets FSGS, with Phase 2a trial planned for Q2-2026; IC 100 is in preclinical stage targeting cardiometabolic conditions.
Company delisted from Nasdaq in October 2025, now trades on OTCQB under ZVSA.
Financial highlights
Net loss for 2025 was $25.0 million, up from $9.4 million in 2024, driven by an $18.6 million impairment charge.
Research and development expenses decreased to $1.1 million in 2025 from $1.8 million in 2024.
General and administrative expenses fell to $5.7 million in 2025 from $7.4 million in 2024.
Cash at year-end 2025 was $0.1 million, with a working capital deficit of $12.4 million.
Accumulated deficit reached $137.6 million as of December 31, 2025.
Outlook and guidance
Cash on hand only sufficient for month-to-month operations; additional financing required to continue development.
Plans to raise capital through equity, debt, or strategic partnerships; no assurance of success.
Anticipates continued operating losses and negative cash flows for the foreseeable future.
- All four shareholder proposals were approved, with board and management updates provided.ZVSA
AGM 202418 Jan 2026 - IC100 and VAR-200 advance toward key clinical milestones, targeting obesity and kidney disease.ZVSA
Life Sciences Investor Forum13 Jan 2026 - Biopharma seeks up to $100M via flexible securities shelf amid pipeline progress and going concern risk.ZVSA
Registration Filing16 Dec 2025 - Biopharma registers 1.6M shares for resale; faces major funding needs and going concern risk.ZVSA
Registration Filing16 Dec 2025 - Registering 478,600 shares for resale, company faces urgent funding needs and going concern risks.ZVSA
Registration Filing16 Dec 2025 - Registering 4.2M shares for resale tied to warrants, with major funding needs and early-stage pipeline.ZVSA
Registration Filing16 Dec 2025 - Annual meeting covers director election, auditor, equity plan, and warrant-related stock issuance.ZVSA
Proxy Filing2 Dec 2025 - Shareholders will vote on director elections, auditor ratification, equity plan, and major warrant issuances.ZVSA
Proxy Filing2 Dec 2025 - Shareholders will vote on director elections, auditor, equity plan, and major share issuances.ZVSA
Proxy Filing2 Dec 2025
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Next ZyVersa Therapeutics earnings date
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