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Ultragenyx Pharmaceutical
Ultragenyx Pharmaceutical (RARE) investor relations material
Ultragenyx Pharmaceutical Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary12 Feb, 2026
Executive summary
2025 total revenue reached $673 million, a 20% increase year-over-year, driven by strong growth in Crysvita and Evkeeza sales, with products now reaching patients in over 35 countries.
Strategic restructuring, including a 10% workforce reduction (~130 employees), aims to align resources, reduce expenses, and achieve profitability by 2027.
2026 is expected to be a pivotal year with two potential approvals (MPS IIIA and GSDIa) and pivotal Phase 3 data in Angelman syndrome, advancing first-ever treatments for rare diseases.
Financial highlights
2025 total revenue reached $673 million, up 20% from 2024 and above guidance.
Product contributions: Crysvita $481M (+17%), Dojolvi $96M (+9%), Evkeeza $59M (+84%), Mepsevii $37M.
Fourth quarter 2025 revenue was $207 million, up 25% compared to Q4 2024.
Net loss for 2025 was $575 million, or $5.83 per share.
Year-end cash, cash equivalents, and marketable securities totaled $738 million.
Outlook and guidance
2026 revenue from current products projected at $730–$760 million, representing 8%-13% growth, excluding new launches.
Crysvita guidance: $500M-$520M; Dojolvi: $100M-$110M.
Combined R&D and SG&A expenses for 2026 expected to be flat to down low single digits versus 2025.
2027 R&D expenses projected to decrease 38% from 2025, with combined R&D and SG&A down at least 15%.
Path to profitability in 2027 relies on continued double-digit growth from current products, contributions from new launches, and monetization of two PRVs.
Restructuring impact on 2026 catalyst execution
UX111 resubmission timeline and approval impact
Crysvita Brazil ordering patterns impact 2026
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Next Ultragenyx Pharmaceutical earnings date
Q1 20265 May, 2026
Ultragenyx Pharmaceutical
Next Ultragenyx Pharmaceutical earnings date
Q1 20265 May, 2026
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Frequently asked questions
Ultragenyx Pharmaceutical Inc. is a biopharmaceutical company dedicated to developing and commercializing therapies for rare and ultra-rare genetic diseases. The company's focus includes treatments for metabolic disorders, bone diseases, and other conditions with significant unmet medical needs. Ultragenyx leverages innovative research and targeted approaches to address complex diseases that often lack effective therapies.The company is headquartered in Novato, California, and its shares are listed on the NASDAQ.
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