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Novartis (NOVN) investor relations material

Novartis Investor Update summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Investor Update summary30 Oct, 2025

Strategic focus and innovation in immunology

  • Immunology is a core therapeutic area, leveraging internal R&D and external partnerships to address high unmet needs in immune-mediated diseases, including T-cell and B-cell-driven conditions.

  • The portfolio includes small molecules, monoclonal antibodies, bispecific agents, and advanced CAR-T therapies, aiming to break efficacy ceilings and deliver patient-centric solutions.

  • Advancing 'pipeline-in-a-pill' products across modalities, with a focus on immuno-dermatology, systemic autoimmunity, allergies, and arthritides.

RHAPSIDO (remibrutinib) launch and market opportunity

  • RHAPSIDO (remibrutinib) approved in the U.S. as the first targeted oral BTK inhibitor for CSU, with a clean safety profile, no boxed warning, and broad label.

  • Demonstrated rapid onset and robust efficacy in REMIX-1 and REMIX-2 trials, with 50% of patients achieving well-controlled disease at week 12.

  • Positioned to fill a treatment gap after antihistamine failure and before biologics, targeting a market about half the size of psoriasis and focusing on 400,000+ antihistamine-uncontrolled CSU patients.

  • US launch strategy focuses on allergists and dermatologists, with commercial infrastructure covering 70% of HCPs and 100% of high-volume prescribers, leveraging bridge programs and rapid access strategies.

  • Indication expansion planned for CIndU, hidradenitis suppurativa, food allergy, multiple sclerosis, and myasthenia gravis, leveraging existing commercial synergies.

Ianalumab/lanalumab in Sjögren's disease: clinical and commercial outlook

  • Ianalumab/lanalumab, a dual-mechanism BAFF receptor antibody, showed statistically significant and clinically meaningful benefit in two global phase III NEPTUNUS trials for Sjögren's disease.

  • Achieved rapid, sustained reduction in systemic disease activity (ESSDAI), improved patient and physician-reported outcomes, and preserved salivary function.

  • Safety profile comparable to placebo, with no new safety signals.

  • FDA fast-track designation in place; global regulatory submissions planned for H1 2026, with long-term extension studies ongoing.

  • Positive data in Sjögren's de-risks ianalumab/lanalumab's potential in other B-cell-driven diseases, with readouts expected in SLE, lupus nephritis, and systemic sclerosis.

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Frequently asked questions

Swiss Pharmaceuticals

Novartis International AG is a Swiss multinational pharmaceutical corporation headquartered in Basel, Switzerland. Established in 1996 through the merger of two companies, Novartis has cemented its place as one of the world's largest and most influential pharmaceutical companies with operations in over 150 countries. The company's portfolio includes a range of medicines, generic drugs, eye care devices, and consumer health products.

Roots in Swiss Pharmaceutical Companies

Novartis can trace its roots in two Swiss chemical companies, Ciba-Geigy and Sandoz, which had both been active in the global pharmaceutical industry for over a century before their merger. The fusion in 1996 aimed to leverage their combined strength in research and development, resulting in a global pharmaceutical behemoth. Novartis has since consistently ranked among the largest healthcare companies globally, partly due to its strong commitment to the development of new treatments.

A Diversified Pharmaceutical Powerhouse

Novartis operates under three main divisions: Innovative Medicines, Sandoz (generics), and Alcon (eye care). The Innovative Medicines division also referred to as the pharmaceuticals division, is dedicated to developing, manufacturing, and marketing patented prescription drugs. It includes two business units: Novartis Oncology and Novartis Pharmaceuticals, which target various therapeutic areas, including oncology, cardiology, respiratory, neuroscience, and ophthalmology, to name a few. Sandoz, the generics division of Novartis, provides high-quality, affordable medicines that treat some of the most prevalent healthcare issues. Lastly, the Alcon division focuses on eye care, manufacturing medical devices and products for eye care professionals and patients. They operate in the same field as companies such as Roche, Sanofi, Pfizer, and other large pharmaceutical companies.

Keeping Up With the Times

While remaining at the forefront of pharmaceutical innovation, Novartis continuously aims to refine its product portfolio and adapt to the ever-evolving healthcare landscape. The company has made significant strides in gene and cell therapies, most notably with Kymriah, a CAR-T cell therapy for certain types of blood cancers. Moreover, Novartis is working in digital health, employing data science and digital technologies to aid in drug discovery, patient care, and even the way clinical trials are conducted. The goal is to make treatments more personalized and more efficient, further enhancing patient outcomes.

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